Abstract
A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced into clinical development.
MeSH terms
-
Administration, Oral
-
Animals
-
Biological Availability
-
Carbamates / chemical synthesis*
-
Carbamates / pharmacokinetics
-
Carbamates / pharmacology
-
Dogs
-
Esters
-
Growth Hormone / blood
-
Growth Hormone / metabolism*
-
Human Growth Hormone / metabolism
-
Humans
-
Macaca fascicularis
-
Rats
-
Solubility
-
Structure-Activity Relationship
-
Tetrazoles / chemical synthesis*
-
Tetrazoles / pharmacokinetics
-
Tetrazoles / pharmacology
-
Water
Substances
-
4-(hydroxybutyl)carbamic acid 2-(5-(1-(2-amino-2-methylpropionylamino)-2-benzyloxyethyl)tetrazol-1-yl)ethyl ester
-
Carbamates
-
Esters
-
Tetrazoles
-
Water
-
Human Growth Hormone
-
Growth Hormone